A-Beta Metabolism and Alzheimer's Disease (Neuroscience by Takaomi Comings Saido

By Takaomi Comings Saido

Beta-secretase M. Citron Alpha-secretases S. Ishiura ADAM 10/alpha secretase and presenilins/gamma secretase in APP processing and notch signaling D. Hartmann Gamma-secretase and presenilin M. Wolfe Biochemistry of gamma-secretase (tentative identify) S. Sinha Presenilin and intracellular protein delivery Degradation of Abeta by way of neprilysin T.C. Saido Degradation of Abeta through endothelin-converting enzyme C. Eckman Degradation of Abeta through insulin-degrading enzyme Lipid raft and Abeta metabolism T. Golde Lipid raft and Abeta accumulation M. Morishima-Kawashima and Y. Ihara Transport-dependent clearance of Abeta B. Zlokovic Abeta vaccination C. Lemere

Show description

Read Online or Download A-Beta Metabolism and Alzheimer's Disease (Neuroscience Intelligence Unit 7) PDF

Similar nonfiction_3 books

The Barbary Corsairs: The End of a Legend, 1800-1820 (Ottoman Empire and It's Heritage) (v. 29)

From 1516 to 1830, the Barbary corsairs ruled the Ottoman provinces of Algiers, Tunis and Tripoli. The years among 1800-1820 have been the most important. until eventually 1805, a surprising revival of privateering permits the writer to give the lads, the practices and the implications won through the privateers. From 1805 to 1814, the Maghrib states gave up an exceptional a part of privateering on behalf of transportation and seaborne exchange, benefiting from their neutrality throughout the Napoleonic wars.

Technology-Enhanced Systems and Tools for Collaborative Learning Scaffolding

Technology-Enhanced structures and instruments for Collaborative studying Scaffolding is an important study subject matter in CSCL and CSCW study group. This publication provides up to date study techniques for constructing technology-enhanced structures and instruments to aid practical on-line collaborative studying and paintings settings.

Extra resources for A-Beta Metabolism and Alzheimer's Disease (Neuroscience Intelligence Unit 7)

Example text

Kitazume S, Tachida Y, Oka R et al. Alzheimer’s β-secretase, β-site amyloid precursor protein cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proc Natl Acad Sci 2001; 98:13554-13559. 43. Lichtenthaler S, Seed B. The aspartyl protease BACE regulates the shedding of p-selectin glycoprotein ligand-1. Neurobiol Aging 2002; 23:S175-S176. 44. Holsinger RMD, McLean CA, Masters CL et al. BACE and β-secretase product CTFβ are increased in sporadic Alzheimer’s disease brain.

1. ADAM family +: proteolytic activity confirmed; -: not confirmed. 15 When we transfected APP695-LAA in which HHQK of Aβ13-16 is replaced with LHHAA to confer greater resistance to α-secretory cleavage, phorbol ester failed to activate α-cleavage, indicating that regulated cleavage is conducted by ADAM9. We also found that a general metalloprotease inhibitor SI-27 inhibited the phorbol ester-induced increase in sAPPα secretion together with concomitant increase in sAPPβ secretion. 14 Purified recombinant mADAM9 could cleave APP in vitro at α-cleavage site.

38. Saido TC, Iwatsubo T, Mann DMA et al. Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques. Neuron 1995; 14:457-466. 39. Russo C, Schettini G Saido TC et al. Preferential deposition of truncated amyloid-β peptides in brain of presenilin 1 gene mutation carriers. Nature 2000;, 405: 531-532. 40. Jarrett JT, Lansbury Jr PT. Seeding “one-dimensional crystallization” of amyloid: a pathogenic mechanism in Alzheimer’s disease and scrapie? Cell 1993; 73(6):1055-8.

Download PDF sample

Rated 4.74 of 5 – based on 26 votes