By Joseph C. Arcos, Yin-Tak Woo, Mary F. Argus
Chemical Induction of melanoma: Structural Bases and organic Mechanisms quantity IIIA offers with the natural and biochemical ideas in the back of cancer.
This quantity comprises the continuation of quantity IIA, which tackles structure-activity relationships of chemical cancer causing agents, the impression of chemical reactivity, molecular geometry, and metabolism on carcinogenic task. less than this is often non-conjugated natural compounds.
The textual content is usually recommended for medical professionals, natural chemists, and biochemists with a complicated wisdom in biochemistry and natural chemistry and wish to understand extra the biochemical approaches of melanoma.
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Extra info for Aliphatic Carcinogens. Structural Bases and Biological Mechanisms
Lymphatic s y s t e m (i. ) Lung, ovary, lymphatic s y s t e m (i. ) Lung (i. ) Skin (topical with croton oil) M a m m a r y gland (i. ) No significant effect (topical with croton oil promotion) (62) (53) Lung (i. ) P e r i t o n e u m (i. ) (64) No significant effect (topical with croton oil promotion) Mouse, — Rat, Charles River CD Mouse, Swiss Mouse, A / J Mouse, albino S Rat, — Mouse, albino S Rat, Charles River CD Mouse, Swiss Mouse, A / J Mouse, albino S Lung (i. ) Lung (i. ) None (s. ) Mouse, A / H e Mouse, A/He Rat, Sprague-Dawley Phenestrin p - [bis(2-chloroethyl)amino ]phenylacetic acid cholesterol e s t e r Estradiol M e s t r a - 1 , 3, 5(10)-triene-3, 17/9 diol bis D-di(2-chloroethyl)-amino ]pheny lac etate F o r s t r u c t u r a l formulas see Table VIII.
152) were the first to detect the presence of bis(ß-chloroethyl) ether and bis(/3-chloroisopropyl) ether in con taminated river water. Investigation of the cause of odor of the Kanawha River at Nitro (West Virginia) led to the qualitative identification of these compounds as two of the pollutants. The presence of bis(/3-chloroisopropyl) ether in river water and finished drinking water was also noted at Evansville (Indiana) by Kleopfer and Fairless (95). An industrial outfall located about 150 miles upstream from the Evansville water intake was found to be the probable source of the pollutant.
F i r m s heavy exposure for m o r e than 5 y r A l b e r t et al. ( 1 4 1 f Lernen et a l . ( 1 3 9 ) 5 4 F i g u e r o a e t a_L_ ( 1 3 6 ) p r o s p e c t i v e study 5 No. 5/1000/yr 8. 48/1000/yr 5/136/18 yr 4. 59/1000/yr 0. 5 4 / 1 3 6 / 1 8 y r 0. 5 7 / 1 0 0 / 5 y r 0. 0 2 4 / 3 2 / 1 6 y r C a n c e r i n c i d e n c e in c o n t r o l g r o u p (Y ) 3. 96 208 Increased risk (X/Y) Increased Risk of Respiratory Cancers after Exposure to Bis(chloromethyl) Ether and/or Chloromethyl Methyl Ether Table XVIII < 0.