Biopsy Diagnosis of Peripheral Neuropathy by Juan M Bilbao, Robert E Schmidt

By Juan M Bilbao, Robert E Schmidt

This can be a normal reference for citizens in neurology and neuropathology, and can be an invaluable ebook within the electron microscopy laboratory. It offers a pragmatic method of interpretation of nerve biopsy, and has amazing micrographs protecting either mild and electron microscopy. New illness entities are mentioned with advances within the realizing of the pathogenesis of every neuropathy. an entire literature evaluation as regards to subcutaneous nerve biopsy is observed by way of scientific beneficial properties, and histogenesis of all human polyneuropathies

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Extra resources for Biopsy Diagnosis of Peripheral Neuropathy

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However, the two are easily distinguished on the basis of histochemical and ultrastructural features (Figure 15-1). We have on occasion observed in the endoneurium of abnormal nerves a more mature stage of elastic fiber formation, elaunin (Figure 2-13B). There remains an optically empty component to the interstitium, composed of water and various macro­ molecules. 4^ 27 Chapter 2 Normal Anatomy of Peripheral (Sural) Nerve Β Fig. 2-13 Aggregates of oxytalan are often seen in the subperineurial region (A), whereas elaunin (B: arrows) is uncommon.

When a regenerating axon is re-myelinated, the internodes tend to be a uniformly short length of about 200-400 μm. ^^ Thus, in axonal degeneration and regeneration the histogram demonstrates numerous fibers of various diameters with uniformly short internodes. In contrast, random segmental demyelination results in residual long inter­ nodes intermingled with short remyelinated inter­ nodes, producing a wide range of internode lengths within the same fiber. This technique can thus provide information about axon and myelin alterations in a peripheral nerve.

29. Pollock M, Nukada H, Allpress S, et al. Peripheral nerve mor­ phometry in stroke patients. J Neurol Sei 1984;65:341-352. 30. Prineas JW, McLeod JG. Chronic Relapsing Polyneuritis. J Neu­ rol Sei 1976;27:427-458. 31. Schaumburg HH, Berger AR, Thomas PK. Disorders of Periph­ eral Nerves, Edition 2. Philadelphia: F A . , 1992, 45. 32. Schroder JM, Bohl J, Brodda K. Changes of the ratio between myelin thickness and axon diameter in the human developing sural nerve. Acta Neuropathol 1978;43:169-178.

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