By Paula Trahan Rieger
This article presents the root to appreciate and practice this healing modality. the talents essential to take care of sufferers who obtain it are incorporated. It additionally presents additional perception into the sphere of biotherapy, as good as a viewpoint of the data got to this point. management and nursing administration of BRM unwanted side effects are delineated besides components for destiny nursing examine. this article is meant for oncology nurses, yet others concerned with biotherapy will locate it to be a helpful source.
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Additional resources for Biotherapy: A Comprehensive Overview (Jones and Bartlett Series in Oncology)
The underlying hypothesis of cytotoxic drug research is that more is better. Thus, a critical first step in evaluating a new drug is to determine the maximum tolerated dose (MTD). This step is also important for biological agents because the agent may exert the best antitumor effect at the MTD. The MTD, however, may not be the same as the optimal biological dose (OBD). Early clinical trials of biological agents demonstrated that immunologic effects occurred at doses lower than Page 9 the identified MTD.
The potential clinical impact of TNF depends on an increased understanding of its cellular mechanisms and tumor cell resistance (Frei and Spriggs, 1989). Further discussion of clinical trials and toxicity experienced by patients who receive TNF can be found in Chapter 8. Summary Biotherapy is established with surgery, chemotherapy, and radiotherapy as a treatment modality for cancer. Clearly, much has been achieved in a very short period of time, but a vast amount about these agents and their uses remains to be discovered, understood, and evaluated in preclinical and clinical trials.
Biological agents have pleiotropic effects, that is, they possess multiple actions: agents are capable of producing immunologic actions, other biological effects, or a combination of these activities. Biotherapy is generally used as a global term to describe this approach. BRMs, or more commonly now, biological agents, refer to the agents used within this therapeutic modality. No one classification system exists for biotherapy. In addition, because agents often possess multiple biological actions, it is difficult to classify them.