By Andrea C. Gore Phd (auth.), Andrea C. Gore Phd (eds.)
Endocrine Disrupting chemical compounds: From uncomplicated learn to scientific perform is the 1st booklet that gives complete assurance of the 3 most crucial subject matters within the box of EDC study: the fundamental biology of EDCs, really their results on reproductive structures; EDC results on people and flora and fauna, together with biomedical issues; and power interventions and sensible suggestion for facing the matter of EDCs. This e-book offers a translational method of EDC learn, spanning either easy biology and scientific purposes, and offers a severe hyperlink among the laboratory and the physicians’ workplace. Scientists and physicians engaged in EDC experiences or perform will locate that this quantity bargains perception throughout all components of EDC study, together with clarifying the mechanisms for EDC results, figuring out the adversarial impacts of EDCs on people and flora and fauna, and delivering ideas to the issues created by means of exposures to EDCs.
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Additional info for Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice
Sample text
6. CONCLUSIONS The organizational and functional changes reported to date provide important pieces of evidence for the understanding of how xenoestrogen exposures, and BPA exposure in particular, affect fetal development and adult function of the female reproductive system in mammals. Although low-level exposure to BPA or other xenoestrogens during adulthood may not have dramatic effects in females, it is clear that when exposure occurs in utero or during the perinatal period, they can exert significant and lasting effects on the development of the female reproductive tract, estrogen-sensitive targets, and reproductive axis function.
Environ Health Perspect 2002; 110:A703–A707. 46. Ikezuki Y, Tsutsumi O, Takai Y, Kamei Y, Taketani Y. Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Hum Reprod 2002; 17:2839–2841. 28 Part I / The Basic Biology of Endocrine Disruption 47. Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, Needham JL. Urinary concentrations of bisphenol A and 4-Nonylphenol in a human reference population. Environ Health Perspect 2005; 113:391–395.
Evidence that Environmental Endocrine Disruptors Alter Male Reproductive Tract Developmental Processes A majority of the focus on EDCs in the past has been directed to study chemicals with estrogen-like activity. However, based on our summary of the basic biology of male reproductive tract development in mammals, it is evident that chemicals with anti-androgenic activity will also constitute a mechanism of equal, if not greater, importance, because androgens are fundamental and critical to establishing the male phenotype.