Endogenous Stem Cell-Based Brain Remodeling in Mammals by Marie-Pierre Junier, Steven G. Kernie

By Marie-Pierre Junier, Steven G. Kernie

This textual content highlights the endogenous regenerative power of the crucial anxious approach in neonates and juveniles and discusses attainable methods it would be manipulated for clinical reasons. the 1st part offers a descriptive precis of the salient steps of human mind improvement with a dialogue of comparisons with different mammalian brains. It additionally presents a old point of view on our figuring out of ongoing mind improvement in the course of the lifespan and serve to introduce the concept that of mind plasticity following harm. the second one half is dedicated to the endogenous reparative capability of the mind, together with its barriers, and articles concentrating on outlined pathologies (e.g. anoxia/hypoxia, epilepsy, irritating mind damage and tension) in animal versions and in people pinpoint eventual methods those pathologies can be manipulated. The 3rd and ultimate makes a speciality of the "dark aspect" of stem cells for mind fix or of the manipulation of spontaneous adaptive occasions after harm (e.g. genomic instability, sensitization to cancerous transformation and faulty neural networks).

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