By Jonas Hannestad
In his thesis Fluorescence in Bio-inspired Nanotechnology, Jonas Hannestad describes the evolving box of DNA nanotechnology in a lucid and simply available manner. A primary topic within the thesis is how organic buildings and mechanisms represent a foundation for the layout of novel applied sciences. Hannestad discusses how self-assembled, nanometer-scale DNA constructs could be functionalized utilizing fluorescent labeling. specifically, he highlights how purposes are in response to fluorescence resonance strength move (FRET). one other very important contribution is the improvement of a lipid monolayer platform for the step by step meeting of DNA nanoconstructs. The paintings within the thesis relies on 5 peer-reviewed papers released in high-profile journals, all of which contain significant contributions from the author.
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Fluorescence in Bio-inspired Nanotechnology: First as Probe, Then as Function
In his thesis Fluorescence in Bio-inspired Nanotechnology, Jonas Hannestad describes the evolving box of DNA nanotechnology in a lucid and simply obtainable method. A significant subject matter within the thesis is how organic buildings and mechanisms represent a foundation for the layout of novel applied sciences. Hannestad discusses how self-assembled, nanometer-scale DNA constructs will be functionalized utilizing fluorescent labeling.
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Since many of the devices rely on excitation energy transfer through multiple fluorophores, it is logical to start the discussion with the light-harvesting complexes of photosynthetic bacteria. These advanced self-assembled systems rely on energy transfer in multiple steps to deliver excitation energy to the bacterial reaction center and has served as inspiration for the design of many of the devices discussed in this chapter. 1 Natural Light-Harvesting Photosynthetic organisms have developed an intricate set of chromophoric arrangements to gather the energy from sunlight.
It also enables, using different techniques, the generation of complex patterns [67, 68]. One example where the computational function have been more direct is DNA-based logic circuits. There are a number of examples of groups who have constructed logic circuits of varying complexity, but all relying on advanced DNA structure designs [57, 69, 70]. Using toehold-based assemblies, Qian and Winfree [65] created a series of DNA-based logic circuits using fluorescence as a reporter function. Toehold designs are well suited for computational applications because they enable the creation of selection-functions with high simplicity and low number of incorporated DNA strands.
12b and τ′B is the fluorescence lifetime of B in presence of the acceptor C. Finally, the sensitized emission from fluorophore C can be described as a function of energy transfer in both one and two steps. 15 Etot denotes the total energy transfer to fluorophore C, both through the two-step process (A–B–C) and directly from A to C. 15 it is possible to extract all inter-chromophoric distances by measuring the quenching of donor A, the sensitized emission of B as well as the sensitized emission of C.