By Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov
This identify will specialise in the research of human interphase chromosomes and its relation to healthiness and illness. Orchestrated association and human genome functionality in interphase nuclei on the chromosomal point were again and again proven to play an important position in quite a few uncomplicated organic strategies interested in consciousness and inheritance of genetic info inside and among species. present biomedical sciences of post-genomic period refocus uncomplicated and utilized reviews of interphase nuclei genetics and genomics with particular realization to interphase chromosome habit in healthiness and disease. also, similar approaches are a objective of stories elucidating the position of interphase chromosome habit in the course of improvement, chromosome/DNA replication, DNA reparation and so on. reports of interphase nuclei have an considerable influence on various parts of biomedical sciences comparable to mobilephone biology, neurobiology, melanoma learn, developmental biology, epigenetics, cytogenetics, and clinical genetics, as a complete. in addition, improvement of leading edge and emergent applied sciences to research interphase nuclei are heavily linked to program of those ideas in medical, diagnostic and learn perform to unravel reproductive difficulties (including infertility and spontaneous abortions), to enquire congenital malformations (including these produced by means of aneuploidy and different chromosome abnormalities); genetic ailments (including cardiac, immune, neurological and psychiatric diseases), and cancer. This name will function a resource of recent worthwhile info and promising rules for a large viewers of execs in biomedicine together with researchers, scientists, and healthcare execs in human genetics, cytogenetics, and developmental biology.
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Human Interphase Chromosomes: Biomedical Aspects
This identify will specialise in the learn of human interphase chromosomes and its relation to wellbeing and fitness and sickness. Orchestrated association and human genome functionality in interphase nuclei on the chromosomal point were many times proven to play an important function in a number of uncomplicated organic techniques inquisitive about recognition and inheritance of genetic info inside and among species.
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Trends Genet 28:464–471 Cafourkova A, Luka-ova E, Kozubek S, Kozubek M, Govorun RD, Koutna I, Bartova E, Skalnikova M, Jirsova P, Pasekova R, Krasavin EA (2001) Exchange aberrations among 11 chromosomes of human lymphocytes induced by gamma-rays. Int J Radiat Biol 77:419–429 Carter D, Chakalova L, Osborne CS, Dai Y-F, Fraser P (2002) Long-range chromatin regulatory interactions in vivo. Nat Genet 32(4):623–626. 1038/ng1051 Cavalli G (2007) Chromosome kissing. Curr Opin Genet Dev 17:443–450 Chambeyron S, Bickmore WA (2004) Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription.
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