By F. Ginhoux, L. G. Ng, M. Merad (auth.), Marcel B.M. Teunissen (eds.)
This quantity of present issues in Microbiology and Immunology covers diversified themes concerning intradermal immunization. The chapters spotlight the effectiveness of intradermal immunization in experimental animal versions or in medical perform, all aiding the view that intradermal immunization is at the very least pretty much as good as different immunization routes. protecting in brain that present vaccines usually are not specifically designed for intradermal immunization, yet convey similar potency even at decreased dosages, this underlines the nice capability for the outside as a vaccination web site. optimistically, the assessment during this quantity will motivate vaccine designers to target this promising immunization path, and likewise, to encourage them to improve vaccines which are in particular optimized for intradermal immunization.
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Additional info for Intradermal Immunization
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M. Teunissen et al. The epidermis is firmly fixed to the basement membrane, which separates the epidermis from the underlying connective tissue called the dermis (Fuchs and Raghavan 2002; Segre 2006; Proksch et al. 2008). Because of the ridged shape of the epidermis, the dermo-epidermal junction has an undulating appearance in cross-sections of the skin (Fig. 1). The dermis varies in thickness (from 1 mm on the face to 4 mm on the back) and is mainly composed of a mucopolysaccharide gel held together by a collagen- and elastin- containing fibrous network rendering the tissue tough and resilient.
Haniffa and M. P. Collin Abstract Dendritic cells (DC) are the key initiators and regulators of any immune response which determine the outcome of CD4+ and CD8+ T-cell responses. Multiple distinct DC subsets can be distinguished by location, phenotype, and function in the homeostatic and inflamed human skin. The function of steady-state cutaneous DCs or recruited inflammatory DCs is influenced by the surrounding cellular and extracellular skin microenvironment. The skin is an attractive site for vaccination given the extended local network of DCs and the easy access to the skin-draining lymph nodes to generate effector T cells and immunoglobulinproducing B cells for long-term protective immunity.
J Exp Med 188:1075–1082 Poulin LF, Henri S, de Bovis B, Devilard E, Kissenpfennig A, Malissen B (2007) The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 204:3119–3131 Randolph GJ, Ochando J, Partida-Sanchez S (2008) Migration of dendritic cell subsets and their precursors. Annu Rev Immunol 26:293–316 Roediger B, Ng LG, Smith AL, Fazekas de St Groth B, Weninger W (2008) Visualizing dendritic cell migration within the skin.