By Geert Molenberghs
The linear combined version has develop into the most parametric instrument for the research of constant longitudinal information, because the authors mentioned of their 2000 ebook. with out placing an excessive amount of emphasis on software program, the e-book indicates how the various methods will be carried out in the SAS software program package deal. The authors acquired the yank Statistical Association's Excellence in carrying on with schooling Award according to brief classes on longitudinal and incomplete information on the Joint Statistical conferences of 2002 and 2004.
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Additional resources for Models for Discrete Longitudinal Data (Springer Series in Statistics)
Sample text
14 shows the visual acuity (mean and standard error) by treatment group at baseline, at 6 months, and at 1 year. Visual acuity can be measured in several ways. First, one can record the number of letters read. Alternatively, dichotomized versions (at least 3 lines of vision lost, or at least 3 lines of vision lost) can be used as well. Therefore, these data will be useful to illustrate methods for the joint modeling of continuous and binary outcomes, with or without taking the longitudinal nature into account.
2 The Analgesic Trial These data come from a single-arm clinical trial in 395 patients who are given analgesic treatment for pain caused by chronic nonmalignant disease. 1) 3 : indifferent, ⎪ ⎪ ⎪ 4 : bad, ⎪ ⎪ ⎪ ⎩ 5 : very bad. 1), but Chapter 18 will consider the ordinal version of the outcome. Apart from the outcome of interest, a number of covariates are available, such as age, sex, weight, duration of pain in years prior to the start of the study, type of pain, physical functioning, psychiatric condition, respiratory problems, etc.
32 3. 1. Epilepsy Study. Frequency plot of the post-randomization total number of epileptic seizures, over both treatment groups. 5. Our response of interest will be the total number of seizures a patient has experienced during the study, after randomization took place. We want to test for a treatment effect on number of seizures, correcting for the average number of seizures during the 12-week baseline phase, prior to the treatment. Let Yi be the total number of seizures for subject i. 1. Note that this histogram does not correct for the fact that the subjects have not been followed for an equal number of weeks.