Nature (Vol. 430, No. 7002, 19 August 2004)

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Publish yr notice: First released in 2002
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From the Hardcover version.

Extra resources for Nature (Vol. 430, No. 7002, 19 August 2004)

Sample text

90 for the 45°, for each of these input states, respectively. 66 (ref. 6) and prove that our teleportation system is operating correctly. 59, respectively, in the absence of active unitary transformation. 5 is due to statistical fluctuations in the observed counts. 04 per second. 97 over a full measurement run. Hence, despite the exposure of our system to the environment, high-fidelity teleportation was still achievable without permanent readjustments. com/nature outside a laboratory. Our system combines for the first time, to our knowledge, an improved Bell-state analyser with active unitary transformation, enabling a doubling of the efficiency of teleportation compared with earlier experiments based on independent photons7,8.

But this raises a question: if integrins and CMG2 are so similar structurally, how does the anthrax toxin tell them apart? Unexpectedly, the crystal structure2 shows that domain II of PA has a small ȋ-hairpin loop (ȋ3–ȋ4) that fits snugly into a groove on the CMG2 surface. Integrins do not have a comparable groove, explaining how PA is able to discriminate between them and CMG2. The smaller portion diffuses away, and the larger part remains bound to the CMG2 receptor, eventually forming a complex of seven PA– CMG2 modules, called a pre-pore6.

9. Blaustein, R. , Koehler, T. , Collier, R. J. & Finkelstein, A. Proc. Natl Acad. Sci. USA 86, 2209–2213 (1989). 10. Bell, S. E. et al. J. Cell Sci. 114, 2755–2773 (2001). 11. Galdiero, S. & Gouaux, E. Protein Sci. 13, 1503–1511 (2004). 8 n&v NEW AM 16/8/04 3:03 pm Page 845 news and views Obituary Francis Crick (1916–2004) Alexander Rich writes: Francis Crick, who died on 28 July at the age of 88, was trained as a physicist but became arguably the most influential biologist of the twentieth century.

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