Nature (Vol. 435, No. 7043, 9 June 2005)

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From the Hardcover variation.

Extra info for Nature (Vol. 435, No. 7043, 9 June 2005)

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The proteins involved in these conditions are known as prions (proteinaceous infectious particles). Prions are increasingly turning up in different organisms, particularly yeast and other fungi. The yeast prions are not functionally or structurally related to their mammalian namesakes, and their ability to convert into fibrillar aggregates is coupled not just to disease but also to the inheritance of genetic traits3,8. Proteins in amyloid fibrils are folded to produce a core region consisting of a continuous array of ȋ-sheets.

Nature 344, 781–784 (1990). 8. Cook, C. E. et al. Science 154, 1189–1190 (1966). 9. Yoder, J. I. Curr. Opin. Plant Biol. 4, 359–365 (2001). 10. , Takeuchi, Y. & Yokota, T. Physiol. Planta 112, 25–30 (2001). 11. Kosuta, S. et al. Plant Physiol. 131, 952–962 (2003). 12. Hijri, M. & Sanders, I. R. Nature 433, 160–163 (2005). COMPUTATIONAL SCIENCE Can get satisfaction Carla P. Gomes and Bart Selman The sheer complexity of some computational problems means they will probably never be solved, despite the ever-increasing resources available.

Perhaps the difference in viscosity between water and deuterium oxide is involved here. Assuming that the reactions occur at the surface of the reactant particles in suspension, rather than in the aqueous phase at low reactant concentrations, particular emphasis should be placed on CO2R N N RO2C 1 N N 2a R = methyl (CH3) 2b R = ethyl (C2H5) CO2R CO2R 3 Figure 2 | Rapid reaction. The reaction of quadricyclane (1) with dimethyl (2a) or diethyl (2b) azodicarboxylate to yield 1,2-diazetidine (3). With the ‘on-water’ protocol, the reaction runs to completion in only 10 minutes, much faster than with other procedures.

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