Principles of molecular neurosurgery by A. Freese, F.A. Simeone, P. Leone, C. Janson, L.D. Lunsford

By A. Freese, F.A. Simeone, P. Leone, C. Janson, L.D. Lunsford

The way forward for neurosurgery might be characterised by way of much less invasive, molecular applied sciences that promise to revolutionize the sphere of neurosurgery and impression the therapy of extra neurological issues, together with neurometabolic illnesses, stroke, dementias, affective and psychiatric illnesses, circulation problems, epilepsy, and others. This ebook encompasses constructing an realizing of the rules underlying the arrival of novel molecular techniques to neurological and neurosurgical illnesses. It Identifies key ideas that may permit dramatic development within the therapy and results of sufferers being affected by a varity of issues affecting the primary worried procedure and spinal axis. This quantity supplies neurosurgeons a very good knowing of the advance of novel molecular and mobile applied sciences that would markedly switch the way in which neurosurgery is practiced within the close to destiny. it's also of targeted curiosity to neurologists, psychiatrists, physiatrists, spinal orthopeadic surgeons, neurobiologists and gene remedy study scientists.

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Vaccaro A, Betz R, Zeidman S (eds): Principles and Practice of Spine Surgery. Mosby Publisher, 2003, chaps 6, 28. Shekar N. Kurpad, MD, PhD Department of Neurosurgery, Medical College of Wisconsin 9200 West Wisconsin Avenue, Milwaukee, WI 53226 (USA) Tel. edu Kurpad/Lifshutz 36 Freese A, Simeone FA, Leone P, Janson C (eds): Principles of Molecular Neurosurgery. Prog Neurol Surg. Basel, Karger, 2005, vol 18, pp 37–51 Gene Therapy for Degenerative Disc Disease Joseph Kim, Lars G. Gilbertson, James D.

Tissue Cell 1982;14:359–369. 104 Hollander AP, Heathfield TF, Webber C, et al: Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J Clin Invest 1994;93:1722–1732. 105 Okuda S, Myoui A, Ariga K, Nakase T, Yonenobu K, Yoshikawa H: Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells. Spine 2001;26:2421–2426. 106 Thompson JP, Oegema TR Jr, Bradford DS: Stimulation of mature canine intervertebral disc by growth factors.

63] found that women with smaller numbers of tandem repeats in the aggrecan gene had more severe disc degeneration. Annunen et al. [64] identified mutations in the type IX collagen ␣-2 gene which causes a single codon substitution (tryptophan for glutamine) leading to disc degeneration in 4% of the Finnish back pain population. Another defect in the ␣-3 chain of type IX collagen was shown to be associated with an elevated risk of disc degeneration [65]. ru 17 have been linked with disc degeneration in elderly Japanese patients [69].

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