Recent Progress in Atherosclerosis Research by N. Simionescu, A. Sima, A. Dobrian (auth.), A. Roessner, E.

By N. Simionescu, A. Sima, A. Dobrian (auth.), A. Roessner, E. Vollmer (eds.)

This monograph on contemporary development in atherosclerosis study provides state-of-the paintings morphological investigations at the cells and their metabolism within the atherosclerotic plaque in situ. The spectrum of equipment comprises immunohistologic and immunoelectron microscopic investigations at the localization of apolipoproteins within the cells of the arterial intima, offering new information at the lipoprotein metabolism in plaque. The collagen metabolism is analysed via in situ hybridization thoughts for demonstrating the synthesis of alternative collagen kinds at the messenger RNA point. focusing on in situ investigations with subtle morpholocial equipment, the frequent dialogue on atherogenesis is targeted at the arterial wall and its morphological adjustments. As morphology is still the root for knowing the pathogenesis of illness, the implications offered right here can be of curiosity not just to pathologists, but additionally to clinicians and researchers operating within the box of biology of atherosclerosis.

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30% type I collagen. In the atherosclerotic intimal plaques a shift in this distribution was observed, collagen type III accounting for only 35% (MCCULLAGH and BALIAN 1975). More recent estimates have claimed that in both normal and diseased arterial intima, 50%-75% of collagen is of type I (MURATA et al. 1986). In vitro studies have demonstrated that LDL particles bind more markedly to collagen type III than to type I. The increase in high ionic strength and pH reduces the binding, indicating the electrostatic nature of the interaction (ESKENASY et al.

Regions with an altered extracellular matrix are very often the site for MRLp in which heteromorphic large lipid droplets and extracellular liposomes appear trapped and linked to the matrix filaments (Fig. 9) (SIMIONESCU 1988; FRANK and FOGELMAN 1989). The role played in the retention of MRLp within the arterial wall has been well documented for proteoglycans, collagens, elastin, and fibronectin. 1 Proteoglycans It is generally believed that amounts of sulfated glycosaminoglycans increase with age and with the cholesterol content of the human aorta, as does the ratio of chondroitin sulfate to derma tan sulfate, whereas the corresponding amounts of hepar an sulfate decrease.

More recent estimates have claimed that in both normal and diseased arterial intima, 50%-75% of collagen is of type I (MURATA et al. 1986). In vitro studies have demonstrated that LDL particles bind more markedly to collagen type III than to type I. The increase in high ionic strength and pH reduces the binding, indicating the electrostatic nature of the interaction (ESKENASY et al. 1984). Immunofluorescence microscopy of fatty streaks has located LDL particles along collagen fibers (HOFF et al.

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