By Sara E. Rosenbaum
Up-to-date with new chapters and subject matters, this booklet offers a complete description of all crucial issues in modern pharmacokinetics and pharmacodynamics. It additionally positive factors interactive machine simulations for college kids to test and detect PK/PD types in action.
• Presents the necessities of pharmacokinetics and pharmacodynamics in a transparent and revolutionary manner
• Helps scholars greater enjoy very important thoughts and achieve a better realizing of the mechanism of motion of gear through reinforcing useful purposes in either the e-book and the pc modules
• Features interactive laptop simulations, to be had on-line via a better half web site at: http://www.uri.edu/pharmacy/faculty/rosenbaum/basicmodels.html• Adds new chapters on physiologically established pharmacokinetic versions, predicting drug-drug interactions, and pharmacogenetics whereas additionally strengthening unique chapters to raised arrange scholars for extra complicated applications
• Reviews of the first variation: “This is a perfect textbook for these beginning out … and in addition to be used as a reference e-book …." (International Society for the examine of Xenobiotics) and “I may suggest Rosenbaum’s publication for pharmacology scholars since it is written from a standpoint of drug motion . . . total, it is a well-written advent to PK/PD …. “ (British Toxicology Society publication)
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Additional info for Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations
Example text
Conversely, a TI of 3 would indicate a small margin of safety. A drug with a small therapeutic ratio will have a narrow therapeutic range. 6 SUMMARY In summary: r Pharmacokinetics may be defined as a study of the relationship between drug concentration and time after the administration of a given dose. It involves the study of all the processes that affect this relationship: that is, a drug’s ADME. Pharmacokinetics represents the first stage in the process of drug response. r In pharmacokinetics, the plasma concentrations of a drug are usually studied.
It is often assumed that the plasma concentration reflects the drug concentration at the site of action. This is generally true and the relationship is often linear. Increases or decreases in the plasma concentration will be reflected by proportional increases or decreases at the site of action, respectively. However, as discussed in subsequent chapters, this is not always the case and a more complex relationship between these two concentrations may exist. It is important to note that although changes in the plasma concentration will usually result in proportional changes in the drug concentration at the site of action, the reverse is not true.
It will allow the drug response to be calculated at any time after any dose. It will allow optimum dosing regimens to be determined and can be used to simulate drug response data in situations not studied clinically. REFERENCE 1. Bauer, L. A. , McGraw-Hill, New York. 2 PASSAGE OF DRUGS THROUGH MEMBRANES Sara E. 5 Clinical Examples of Transporter Involvement in Drug Response References Objectives The material in this chapter will enable the reader to: 1. 2. 3. 4. 5. 6. Distinguish passive diffusion and transporter-mediated passage Distinguish transcellular and paracellular transport Identify membrane and drug factors that control passive diffusion Distinguish uptake and efflux transporters Become familiar with members of the SLC and ABC superfamilies Understand how transporters affect pharmacokinetics and pharmacodynamics Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations, Second Edition.