By Rongling Wu
This publication intends to supply geneticists with the instruments had to comprehend and version the genetic edition for quantitative features in response to genomic facts amassed in mapping study and equip statisticians with the individuality and concepts relating to the exploration of genetic secrets and techniques utilizing their computational talents. This booklet additionally intends to draw researchers towards multidisciplinary examine and to introduce them to new paradigms in genomic technology. during this ebook, the statistical and computational theories utilized to genetic mapping are built hand in hand and a few examples exhibiting the consequences of statistical genomics are brought.
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Extra resources for Statistical Genetics of Quantitative Traits: Linkage, Maps, and QTL
Sample text
In principle, the assay for a genetic marker is not affected by environmental factors. Genetic markers are DNA sequence polymorphisms that show Mendelian inheritance. , segregates in almost every family). However, some dominant markers are also very useful and powerful in particular situations. Molecular markers have many different types. Restriction fragment length polymorphisms (RFLPs) were the first genetic markers that were widely used for genomic mapping and population studies. RFLP markers are obtained by using restriction endonucleases to precisely cleave a genomic DNA fragment containing a particular gene sequence.
First Testing Example). 2, where we have Y1 , Y2 , . . , Yn iid from an N (µ, σ 2 ) population. To test H0 : µ = µ0 vs. 3). In maximizing the numerator, we set µ = µ0 and maximize in σ 2 , giving ˆ02 |y), max L(µ, σ 2 |y) = L(µ0 , σ µ=µ0 where σ ˆ02 = (1/n) n i=1 (yi − µ0 )2 . 3 Hypothesis Testing λ(y) = = = 35 ˆ02 |y) L(µ0 , σ L(ˆ µ, σ ˆ 2 |y) 1 2π σ ˆ02 n/2 n/2 1 2π σ ˆ2 2 n/2 σ ˆ σ ˆ02 exp 1 2ˆ σ02 n i=1 (yi − µ0 )2 exp 1 2ˆ σ2 n i=1 (yi −µ ˆ)2 , which is, in fact, equivalent to the usual t–test.
The mode of inheritance for RAPDs is usually dominant; the sequence either amplifies or not, and one copy cannot be distinguished readily from two copies. Another PCR-based anonymous marker system is amplified fragment length polymorphisms (AFLPs). AFLPs are produced by cleaving genomic DNA using a pair of restriction endonucleases and then ligating adapters to the ends of the DNA fragments. A subset of the fragment is selectively amplified from these ligated fragments. These DNA fragments can be resolved on DNA sequencing gels and have a higher multiplex ratio than RAPDs, often 20–40 markers per gel lane.