By Dieter Häussinger, Editor
Knowing the mechanisms fascinated with liver regeneration is of the most important significance for medical drugs, not just relating to carcinogenesis and diabetes remedy, but in addition for using stem cells for mobile treatment and liver surgical procedure. This graduate-level textual content presents an outline of the present country of information of the molecular mechanisms of liver regeneration. Hepatic stem cells are brought and the $64000 avid gamers keen on regeneration similar to oval cells, bone marrow and stellate cells are reviewed. The telephone signaling pathways that begin liver regeneration and keep an eye on the swap among proliferation and apoptosis are awarded and the position of liver stem cells in tumorigenesis is mentioned. The publication additionally treats the epigenetic law of liver stem cells and the jobs of irritation and angiogenesis in liver regeneration. This compact review of the attention-grabbing regenerative skill of the liver could be of curiosity to graduate scholars and post-docs in molecular biology, biochemistry and drugs.
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Additional info for Liver Regeneration (De Gruyter Textbook)
Example text
353, 638–43. , and Taub, R. (1995). Coexistence of C/EBP alpha, beta, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth. J. Clin. Invest. 96, 1351–65. , and Taub, R. (1993). Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration. J. Clin. Invest. 91, 1319–26. , and Todo, S. (2009). The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositidedependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.
26 2 Oval Cells, Bone Marrow, and Liver Regeneration Mesenchymal stem cells might become an even more suitable source for SC-based therapies than hematopoietic SCs because of their immunological properties: MSCs are less immunogenic and can induce tolerance upon transplantation. , 2009). , 2007). These cells could potentially co-purify with hematopoietic SCs or MSCs and contaminate these cell populations investigated in liver repopulation studies. , 2006). Therefore, the present distinction between hematopoietic SCs and MSCs may become obsolete, given the heterogeneity and possible overlaps of these various BMSC populations, which could share a common stemness core.
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